C-Retard 500 mg capsules
TRADE NAME :
C-Retard 500 mg
GENERIC NAME :
Ascorbic acid
COMPOSITION :
Each Capsule contains:
Active: Ascorbic acid 500 mg Inactive:
Beeswax. Microcrystalline Cellulose. Stearic acid
PHARMACEUTICAL FORM :
Hard gelatin capsule
PHARMACOLOGICAL ACTION :
Ascorbic acid is reversibly oxidized to dehydroascorbic add in the body. These : two forms of the vitamin C are believed to be important in oxidation reductions which is involved in numerous
enzymatic reactions and is the basis of the spectrum of action of vitamin C.
PHARMACOKINETICS :
each capsule of C-retard contains vitamin C retard pellets, which slowly release vitamin c
This leads to high and constant concentration of blood levels
Absorption:
The ascorbic add is first absorbed in the upper segment of the small intestines via active transportation
Distribution:
Vitamin C is distributed in all body tissues.
Metabolism:
Ascorbic acid is partially metabolized into dehydroascorbic add and oxalic acid afterwards.
Elimination:
Elimination is mainly through the kidneys (1-3 gram per day)
INDICATION & USAGE :
Common cold prophylaxis
Vito C (Ascorbic add) deficiency (scurvy)
Promotes healing of wounds following surgery Helps in regeneration processes Helps in teeth formation and gum care During pregnancy and lactation In infectious diseases, viral and bacterial as influenza, rheumatic fever. Typhoid and paratyphoid, etc …
Adjuvant in iron deficiency anaemia Ladies taking oral contraceptives To counter act some of the hazards of smoking and enviromental pollution
DOSAGE AND ADMINISTRATION :
Adults and adolescent over 12 years: The recommended dose is 1 to 2 capsules once daily. Generally, one capsule per day is sufficient To treat infectious disease: 2 capsules daily
CONTRA-INDICATIONS :
Hypersensitivity to the active ingrediants or any of the excipients.
C-retard should not be used in the presence of nephrolithiasis, in patients with uremia and hemochromatosis
SIDE EFFECTS :
C-retard capsule is well tolerated unlike other vitamin C preparations, it does not produce Oxalluria or oxalate renal stone formation and is therefore, well tolerated in renal patients. High doses may cause diarrhea or diuresis.
DRUG INTERACTION :
Oral contraceptives decrease Vitamin C.
Calcitonin leads to greater consumption of vitamin C.
The salicylates inhibit active transport through the intestinal wall.
Tetracyline inhibits the metabolism and intracellular tubular reabsorbtion.
Acetyl salicylic acid, barbiturates and tetracycline increase the urinary excretion of vitamin C. Corticosteroid increase or decrease oxidation of Vitamin C
PREGNANCY AND LACTATION :
There is no evidence of a risk during pregnancy and lactation when the recommended doses are met. Also, C-retard may be taken during pregnancy and lactation
WARNING & PRECAUTIONS :
Vitamin C can contribute to an increase in iron absorption. So caution should be taken in haemochromatosis also certain pathologic disease as Thalasemia.
STORAGE :
Store in a temperature not exceeding 300 C in a dry place.
Keep out of the reach of children.
PACKAGE :
A carton box contains a strip of PVC/ALof10capsules and an insert
INFORMATION FOR PATIENTS :
C-retard does not affect the ability to drive or operate machines.
Taking high doses of C-retard can occasionally cause mild diarrhea and diuretic effect.
Produced by :
Hikma Pharma S.A.E 6th of October City- Egypt
