PROXIMOl COMPOUND Effervescent granules
for expulsion of ureteric stones – Uric acid dissolvent – Urinary antiseptic.
Composition:
Each 100 gm contains:
Halfa bar extract 18.6 mg
Equivalent to 8 mg Proximadiol
Hexamine 6 gm
Piperazine citrate 1 gm
Properties:
PROXIMOl COMPOUND acts as an efficient preparation for expulsion of
ureteric calculi by the unique action of its content of proximadiol (present in the purified extract of Halfa bar) which produces ureteric dilatation while increasing the propulsive movement of the smooth muscles of the ureter, helping the expulsion of the calculi.
PROXIMOl COMPOUND also dissolves uric acid and urate crystals prevents
their deposition in the urinary tract, and these effects are mainly achieved by
the action of Piperazine citrate. In addition to the fore-mentioned properties,PROXIMOl COMPOUND acts as an effective urinary antiseptic due to its content of Hexamine which liberates formaldehyde in the urine.Formaldehyde possesses antibacterial activity against many bacteria responsible for urinary tract infections.
Indications:
– As propulsive for ureteric stones.
– Presence of excess uric acid and urate crystals in urine.
– Urinary tract infections e.g. pyelitis, cystitis, urethritis.
Side effects:
Rarely nausea may occur.
Contraindications:
– Hypersensitivity to any of the components.
– Impairment of renal or hepatic function.
Use In pregnancy:
During pregnancy its safety has not been justified, so it is better to be avoided
during the first trimester as many other new drugs.
Precautions:
Some of the rarely used sulphonamides, e.g sulphamethizole and sulphathiazole, may form insoluble precipitate with the liberated formaldehyde in the urine. so, hexamine containing preparations are not recommended to be used concurrantly with these sulphonamides.
Dosage:
2 teaspoonfuls (or 1 sachet) in 1/2 glass of water three times daily after meals
as directed by physician.
Caution:
To be used only under medical supervision.
Notice:
Patients with urinary lithiasis should be advised to intake plenty of fluids to help extrusion of the calculi.
Packing:
– Waxed sealed glass bottles of 60 gm .
– Sachets of 5 gm. ( Boxes of 12 sachets ).
Storage:
Store below 25° C, protected from humidity.
Produced by
KAHlRA PHARM. & CHEM. IND. CO.
CAIRO – EGypt